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Outsourcing in Drug Discovery, 9th Edition
Publication Date: May 28, 2020
Tags: Biopharma, Contract Research and Manufacturing Orgs, Life Science, Pharma & Biopharma, Pharmaceuticals
Pages: 290
SKU: 20-028
Outsourcing drug discovery represents the initial phase of the drug development process. By outsourcing segments of their drug discovery programs, pharmaceutical and biotechnology companies have discovered a cost-effective strategy that enhances hit-to-lead conversion and early identification of ineffective compounds. Outsourcing accelerates the drug discovery process, transforming the industry from low-end research services to high-value, sophisticated research activities.
Kalorama Information’s report, Outsourcing in Drug Discovery, 9th Edition, delves into current trends shaping the market and offers a detailed analysis of the global landscape, both present and future.
Key Features of the Report:
This extensive market analysis provides crucial data and strategic planning resources for stakeholders in the drug discovery outsourcing market. Key highlights include:
- Global Market Projections: Analysis from 2019 to 2024, including market segments such as Chemistry, Biology, HTS, Lead Optimization, and the overall market.
- Segment Market Share: Insights into the market share of different segments in 2019 and projections for 2024.
- Revenue Analysis: Detailed revenue breakdowns for Chemistry, Biology, HTS, and Lead Optimization services, along with annual growth and market share.
Market Insights:
- Trends Driving Demand: Key trends increasing the need for contract services in drug discovery, including technological advancements, patent expirations, time-to-market pressures, and the shift from fixed to variable costs.
- Globalization of Contract Research: Expansion of international CROs into Asia, particularly China and India, and the rise of outsourcing in Eastern Europe.
- Outsourcing Models and Challenges: Examination of CRO roles, effective communication strategies for partnerships, and IP protection challenges.
COVID-19 Impact Analysis:
No market report today would be complete without considering the impact of the COVID-19 pandemic. This report examines:
- Global Macro Trends and Coronavirus: Broad economic implications of the pandemic.
- Supply Chain Impact: How COVID-19 has disrupted supply chains.
- Cultural Implications: Changes in workplace and cultural norms due to the pandemic.
- R&D Spending: Adjustments in research and development spending in response to COVID-19.
- Opportunities and Challenges: New opportunities created by the pandemic and related challenges, especially in outsourcing to China, India, and Eastern Europe.
Table: Global Drug Discovery Outsourcing Market, 2014-2024 ($ billion)
| Year | Global Market | Percent Increase |
| 2014 | $XX Million | XX% |
| 2015 | $XX Million | XX% |
| 2016 | $XX Million | XX% |
| 2017 | $XX Million | XX% |
| 2018 | $XX Million | XX% |
| 2019 | $XX Million | XX% |
| 2020 | $XX Million | XX% |
| 2021 | $XX Million | XX% |
| 2022 | $XX Million | XX% |
| 2023 | $XX Million | XX% |
| 2024 | $XX Million | XX% |
| Compound Annual Growth Rate | ||
| 2014 – 2019 | XX% | |
| 2019 – 2024 | XX% | |
| 2014 – 2024 | XX% | |
Source: Kalorama Information
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Table of Contents
1: Executive Summary
Overview
-
- Exhibit 1-1: Drug Discovery Timeline: Research to Viable Product to Commercialization
Scope and Methodology
Introduction
- Global Macro Trends and Coronavirus
- Pharmaceutical Industry Trends
- Net Effects of the Coronavirus
The Drug Discovery Process
-
- Exhibit 1-2: The Drug Discovery Process
- Bottlenecks within the Drug Discovery Process
Outsourcing Drug Discovery
- Outsourcing to Increase Efficiency
Offshoring Contract Drug Discovery
- Factors to Consider in Offshore Outsourcing
- Outsourcing to China
- Outsourcing to India
- Outsourcing to Eastern Europe
Drug Discovery Outsourcing Market
- Current Market and Forecast
- Exhibit 1-3: Global Drug Discovery Outsourcing Market, 2014 – 2024 ($ billion)
- Market Analysis by Segment
- Exhibit 1-4: Market Share Drug Discovery Market Segments, 2019 (%; Lead Optimization, Chemistry Services, Biology Services, HTS)
2: Introduction to Outsourcing Drug Discovery
Macroeconomic Environment
- The Coronavirus Economy
- Supply Chain Impact of Coronavirus
- Lifting of Lockdowns
- Cultural Implications of Coronavirus
Biopharma Background
- Number of New Molecular Entities (NMEs) and Biologics License Approved (BLAs) Approved
- Exhibit 2-1: Number of New Molecular Entities (NMEs) and Biologics License Approved (BLAs) That the US FDA Center for Drug Evaluation and Research (CDER) Approved between 2000 – 2019
- R&D Spending and Impact of Coronavirus
- Rising Availability of Talent
- Ramping up the Pipelines
- Exhibit 2-2: Domestic R&D and R&D Abroad, PhRMA Member Companies: 2000 ñ 2018 ($ billion)
Outsourcing Drug Discovery
The Outsourcing Decision
- Developing an Outsourcing Plan
- Decision Criteria
Factors to Consider in Offshore Outsourcing
- Benefits of Global Outsourcing
- Concerns about Global Outsourcing
Selecting a Contract Research Organization
- Introduction
- Choosing the Right CRO
Global Outsourcing
-
- Exhibit 2-3: Selection of Global Drug Discovery Outsourcing Collaborations, 2020
3: The Drug Discovery Process
Introduction
-
- Exhibit 3-1: The Drug Discovery Process
- Drug Discovery Stages
Accelerating the Drug Discovery Process
- Technologies Utilized in Drug Discovery
- Exhibit 3-2: Drug Discovery Timeline: Research to Viable Product to Commercialization
- Exhibit 3-3: Bioinformatics/Pharmacogenomics
- Exhibit 3-4: Causes of New Drug Attrition (%; Unsuitable Bioavailability Profile, Toxicity, Commercial Setbacks, Other)
- Bottlenecks within the Drug Discovery Process
Outsourcing to Increase Efficiency
-
- Exhibit 3-5: Drug Discovery Processes Frequently Outsourced
Outsourcing to Access Novel Technologies
- Bioinformatics
- Lab-on-a-Chip: Microfluidics in Drug Discovery
- Exhibit 3-6: Bioinformatics as a Central Hub
4: Outsourcing Drug Discovery
Overview
- Sales Decline from Lockdown Recession
- Opportunities Created by the Coronavirus
- Shifting Drug Discovery Model
- Exhibit 4-1: A Selection of R&D Facilities Closed or Reduced in Size between 2010 and 2019
Outsourcing Drug Discovery Useful Core Management Tool
Contract Research Organizations
- Introduction
- Role of a CRO
- Outsourcing Models
- Effective Communication Is Essential for a Successful Partnership
- Mitigating the Challenges of Protecting IP Rights
Outsourcing Contract Drug Discovery Offshore
- Introduction
- Robust Growth of Outsourcing Drug Discovery in Asia
Outsourcing to China
- Introduction
- Multi-National Pharmaceutical Companies Establish Research and Development Facilities in China
- Chinese Contract Research Organizations
- Exhibit 4-2: A Selection of Chinese Drug Discovery CROs, 2020
- WuXi AppTec, Chinaís Largest CRO
- First Chinese CRO Alliance
- FDA Offices in China
- China’s Management of Counterfeit Pharmaceuticals, IP Rights and Laws
- Issues Related to Coronavirus
- Slowing Economic Growth
Outsourcing to India
- Introduction
- Drug Discovery Services in India
- Exhibit 4-3: A Selection of Indian Drug Discovery CROs, 2020
- Indiaís Handling of IP Rights and Laws
- FDA Offices in India
- Issues Related to Coronavirus
- Strong Historic Economic Growth
Outsourcing to Eastern Europe
- Introduction
- Eastern European CROs
- Issues Related to Coronavirus
- Exhibit 4-4: A Selection of Major CROs Operating in Eastern Europe, 2020
5: Drug Discovery Outsourcing Market
Overview
Drug Discovery Outsourcing Market
- Current Market and Forecast
- Exhibit 5-1: Global Drug Discovery Outsourcing Market, 2014 – 2024 ($ billion)
- Exhibit 5-2: Contract Drug Discovery Services, by Market Segment, 2014 – 2024 ($ billion)
Market Analysis by Segment
-
- Exhibit 5-3: Market Share of Drug Discovery Market Segments, 2014, in Percent
-
- Exhibit 5-4: Market Share of Drug Discovery Market Segments, 2019, in Percent
-
- Exhibit 5-5: Market Share of Drug Discovery Market Segments, 2024, in Percent
- Chemistry Services Market
- Exhibit 5-6: Chemistry Services Market: Revenues, Annual Growth, and Share of Outsourced Drug Discovery Market, 2014 – 2024 ($ billion)
- Exhibit 5-7: Chemistry Market Revenue by: Building Blocks, Compound Synthesis, Libraries, Process Research, and Other Services, 2019 ($ billion)
- Biology Services Market
- Exhibit 5-8: Biology Services Market: Revenues, Annual Growth, and Share of Outsourced Drug Discovery Market, 2014 – 2024 ($ billion)
- Exhibit 5-9: Biology Market Revenue by: Protein Expression, Structural Analysis, Target Validation, Pathways Analysis, and Other Services, 2019 ($ billion)
- High Throughput Screening Services Market
- Exhibit 5-10: HTS Services Market: Revenues, Annual Growth, and Share of Outsourced Drug Discovery Market, 2014 – 2024 ($ billion)
- Exhibit 5-11: HTS Screening Services Market: Assay Development, Primary Screening, Secondary Screening, 2019 ($ million)
- Lead Optimization Services Market
- Exhibit 5-12: Lead Optimization Services Market: Revenues, Annual Growth, and Share of Outsourced Drug Discovery Market, 2014 – 2024 ($ billion)
- Exhibit 5-13: Lead Optimization Services Market: Early ADME/Tox, Create Analogues, Computational Support, and Other Services, 2019 ($ billion)
Contract Drug Discovery Competitors
- Recent Acquisitions in Drug Discovery Outsourcing, 2014 – 2020
The Evolving Open-Innovation Model Gaining Traction in Drug Discovery
- Alliances between Academic Organizations and CROs
- Exhibit 5-14: A Selection of Collaborations between CROs and Academic Organizations, 2020
- Alliances between the Pharmaceutical/Biotechnology Industries and Academia
- Exhibit 5-15: Alliances between Pharma/Biotech and Academia, 2020
- Alliances between CROs
- Exhibit 5-16: A Selection of Alliances between CROs, 2020
Market Growth Expanding Global Reach and Scale of Drug Discovery Services
-
- Exhibit 5-17: Global Expansion of Contract Drug Discovery Services East and West, 2020
Is Artificial Intelligence (AI) the Future of Drug Discovery?
- Evotec Buys into AI
- Pharmaceutical Companies Collaborate with AI Companies
- Exhibit 5-18: Selected Biopharmaceutical AI Providers, 2020
6: Competitor Profiles
Albany Molecular Research, Inc.
- History and Lines of Business
- Drug Discovery Services
- Financial Data
Aptuit, a Division of Evotec AG
- History and Lines of Business
- Drug Discovery Services
- Financial Data
Asclepia MedChem Solutions
- History and Lines of Business
- Drug Discovery Services
- Financial Data
Asinex Ltd.
- History and Lines of Business
- Drug Discovery Services
- Financial Data
AsisChem Inc.
- History and Lines of Business
- Drug Discovery Services
- Financial Data
Aurelia Bioscience Ltd
- History and Lines of Business
- Drug Discovery Services
- Financial Data
Axxam SpA
- History and Lines of Business
- Drug Discovery Services
- Financial Data
BioDuro
- History and Lines of Business
- Drug Discovery Services
- Financial Data
Charles River Laboratories, Inc.
- History and Lines of Business
- Drug Discovery Services
- Financial Data
Charnwood Molecular
- History and Background
- Drug Discovery Services
- Financial Data
ChemBridge Corp.
- History and Background
- Drug Discovery Services
- Financial Data
Chemical Diversity Inc. (ChemDiv)
- History and Lines of Business
- Drug Discovery Services
- Financial Data
ChemPartner Co., Ltd., subsidiary of ShangPharma
- History and Lines of Business
- Drug Discovery Services
- Financial Data
Chengdu Pioneer Drug Development Co., Ltd.
- History and Lines of Business
- Drug Discovery Services
- Financial Data
Covance Inc. (Laboratory Corporation of America)
- History and Lines of Business
- Drug Discovery Services
- Financial Data
CreaGen Biosciences, Inc.
- History and Lines of Business
- Drug Discovery Services
- Financial Data
Crown Bioscience
- History and Lines of Business
- Drug Discovery Services
- Financial Data
Cyprotex PLC, an Evotec AG Company
- History and Line of Business
- Drug Discovery Services
- Financial Data
Domainex
- History and Lines of Business
- Drug Discovery Services
- Financial Data
Enamine Ltd.
- History and Lines of Business
- Drug Discovery Services
- Financial Data
Eurofins Scientific S.E.
- History and Lines of Business
- Drug Discovery Services
- Financial Data
Evotec AG
- History and Lines of Business
- Drug Discovery Services
- Financial Data
Exelgen Discovery
- History and Lines of Business
- Drug Discovery Services
- Financial Data
GVK Biosciences Private Limited (GVK Bio)
- History and Lines of Business
- Drug Discovery Services
- Financial Data
GenScript USA Inc.
- History and Lines of Business
- Drug Discovery Services
- Financial Data
Hutchison MediPharma, Ltd.
- History and Lines of Business
- Drug Discovery Services
- Financial Data
Jubilant Biosys Ltd. (JBL), a subsidiary of Jubilant Life Sciences Ltd.
- History and Lines of Business
- Drug Discovery Services
- Financial Data
Nanosyn, Inc.
- History and Lines of Business
- Drug Discovery Services
- Financial Data
Olon Ricerca Biosciences
- History and Lines of Business
- Drug Discovery Services
- Financial Data
Pharmaron, Inc.
- History and Lines of Business
- Drug Discovery Services
- Financial Data
Selcia Ltd
- History and Lines of Business
- Drug Discovery Services
- Financial Data
Selvita S.A.
- History and Lines of Business
- Drug Discovery Services
- Financial Data
Shanghai Medicilon, Inc.
- History and Lines of Business
- Drug Discovery Services
- Financial Data
Sundia MediTech Company, Ltd.
- History and Lines of Business
- Drug Discovery Services
- Financial Data
Sygnature Discovery Limited
- History and Lines of Business
- Drug Discovery Services
- Financial Data
TCG Lifesciences Pvt Ltd.
- History and Lines of Business
- Drug Discovery Services
- Financial Data
Viva Biotech, Ltd.
- History and Lines of Business
- Drug Discovery Services
- Financial Data
WuXi AppTec Co. Ltd.
- History and Lines of Business
- Drug Discovery Services
- Financial Data
Appendix: Company Names and Addresses
Company Names and Addresses
- 2-y Chem, Ltd.
- Abgenix
- AbMax Biotechnology
- Absorption Systems
- Acesys Pharmatech
- Actimus Biosciences Pvt. Ltd.
- ActivX Biosciences
- Advinus Therapeutics Pvt. Ltd.
- Advinus Therapeutics Ltd.
- Agios Pharmaceuticals
- Albany Molecular Research, Inc.
- Advinus Therapeutics Ltd.
- Affinium Pharmaceuticals
- Albermarle Corp.
- Alphora Research Inc.
- Ambit Biosciences Corp.
- Amgen, Inc.
- Antabio Pharmaceutical
- Apredica
- Aptuit, LLC
- Asclepia
- Asinex Ltd.
- Asinex
- AsisChem, Inc.
- Astex Therapeutics
- AstraZeneca
- Asymchem Laboratories Co., Ltd.
- Asymchem Laboratories Inc.
- Aurelia Bioscience Ltd
- Aurigene Discovery Technologies Ltd.
- Aurigene Discovery Technologies Limited
- Axxam SpA
- Berg Health
- BioAnaLab Limited
- BioBlocks Incorporated
- Biocentrum Cell Laboratories, a division of Selvita S.A.
- Biocius Life Sciences, Inc.
- BioDuro, Inc.
- BioDuro, Inc./China
- Biogen Idec
- Biolog, Inc.
- Bioneeds
- Bionomics Ltd.
- BioReliance Corporation
- Biovays SAS
- BioVisioN AG
- Boehringer Ingelheim Pharmaceuticals, Inc.
- British Columbia Cancer Agency
- Caliper Life Sciences
- Cambridge Antibody
- Cambridge Major Laboratories, Inc
- Cantab Biopharmaceuticals Ltd,
- CarysBio Holding Ltd.
- Cayman Chemical
- Celera Genomics
- CellCentric Ltd.
- Cell & Molecular Technologies
- Cellzome AG
- Cellzome (UK)
- Cetek Corp.
- Eurofins Advinus Limited
- Charles River Laboratories, Inc.
- Charnwood Molecular
- Charnwood Molecular
- Chemizon, Inc.
- ChemPartner Co., Ltd.
- Chiesi Farmaceutici SP
- Chembiotek
- ChemBridge Corp.
- ChemDiv
- Chemizon, Inc.
- Chemizon Ltd
- ChemModeling, LLC
- Chemotargets SL
- ChemOvation Ltd.
- ChemShop BV
- ComGenex Inc.
- Compugen
- Covance, Inc
- CreaGen Biosciences, Inc.
- Creative BioStructure
- Cresset Drug Discovery
- Crown Bioscience Inc.
- Crown Bioscience Inc./China
- CuraGen Corp.
- Cychem, Inc.
- Cyprotex PLC
- Dalton Chemical Laboratories Inc.
- Debiopharm International SA
- Deltagen
- DiscoveryBioMed, Inc.
- Domainex
- DoubleTwist Inc.
- Dr. Reddyís Laboratories, Ltd.
- Dr. Reddyís Laboratories, Inc.
- Dynogen Pharmaceuticals, Inc.
- EM Industries, Inc.
- Elan Pharmaceuticals
- ElexoPharm GmbH
- Ely Lilly and Company
- Emerald Biostructures
- Enamine LLC
- Enamine Ltd.
- Endo Pharmaceutical
- Ensemble Discovery Corporation
- Epiclone, L.A.
- Evolus Inc.
- Evotec AG
- Evotec AG
- Evotec (Asia) Pte. Ltd.
- Evotec (India) Private Limited
- Exelgen Discovery
- Exscientia
- ExonHit Therapeutics SA
- ExSAR
- Flourous Technologies
- GPC Biotech AG
- GVK Biosciences Private Ltd.
- GVK Biosciences Private Ltd.
- GVK Biosciences Private Ltd.
- Galapagos NV
- GeneFormatics Inc.
- Gene Logic Inc.
- GenScript USA Inc.
- GenScript Biotech Corporation
- GlaxoSmithKline
- Genentech, Inc.
- Genome Therapeutics
- GeneProt
- Genome BioSciences, Inc.
- Genomics Collaborative Inc.
- Genops Bioinformatics Inc.
- GenOway
- GenScript USA Inc.
- GenScript/Japan
- GenScript/China
- Genta, Inc.
- Genezyme Corporation
- Gilead Sciences
- Glaucus Proteomics BV
- Graffinity Pharmaceuticals GmbH
- Gr¸nenthal Group
- HD Biosciences, Inc.
- HitGen Ltd.
- Human Genome Sciences
- Hutchison MediPharma Limited
- Hybrigen
- Hybrigenics SA
- Icagen, Inc.
- Iconix Pharmaceuticals, Inc.
- ICOS Corporation
- ID Business Solutions Ltd.
- Indus Bioscience
- Informax Inc.
- iNovacia
- Inpharmatica
- Insilico
- InterChem
- iThemba Pharma
- Johnson Matthey Pharma Services
- J-Star Research
- Janssen Pharma
- Johnson & Johnson
- Jubilant Life Sciences Ltd.
- Julilant Biosys Ltd.
- Julilant Discovery Center (Noida)
- Kalexsyn
- Kendle International
- Key Organics Ltd.
- Laboratory Corporation of America Holdings
- Lancaster Laboratories
- Lark Technologies, Inc.
- Laxai Corporation
- Laxai Avanti Life Sciences
- Lexicon Genetics Inc.
- Life Chemicals Inc.
- Linden Bioscience
- Ligand Pharmaceuticals, Inc.
- Magellan Laboratories
- Maybridge plc
- Medarex
- Medicilon, Inc.
- Medicilon, Inc.
- Merck KGaA
- MerLion Pharmaceuticals Pte Ltd
- Merrimack Pharmaceuticals, Inc.
- Metabometrix Ltd.
- Metabometrix Ltd.
- Micron Technologies, Inc.
- Morphochem AG
- MPI Research
- Multispan, Inc.
- Myriad Genetics Inc.
- Naeja Pharmaceutical Inc.
- Nanostream, Inc.
- Nanosyn, Inc.
- Navigen Pharma
- NEOMED Institute
- Neurodegeneration Consortium
- Nextgen Sciences Ltd.
- Nicholas Piramal India Limited
- NiKem Research s.r.l.
- NitroMed, Inc.
- Novartis Institute of BioMedical Research
- Numerate, Inc.
- Nycomed GmbH
- OncoDesign SA
- OpGen
- Organix Inc.
- Organomed Corp.
- Orion Pharmaceuticals
- Oxford GlycoSciences Plc
- Parexel
- Pcovery
- Peakdale Molecular Ltd.
- PepTech Corporation
- Pfizer, Inc.
- PharmaCore
- PharmaLink
- Pharmaron
- Pharmaron Beijing Co., Ltd.
- Pharmaron Beijing Limited Co.
- PharmEco
- Pharmidex
- Phenomix Corp.
- Phylos Inc.
- Polyphor Ltd
- PPD, Inc.
- PRECOS Ltd.
- Prestwick Chemical
- Procter and Gamble Company
- Protein Mechanics, Inc.
- Proteome Systems Ltd.
- Proteologics Ltd.
- ProteoMetrics Inc.
- Protogene Laboratories Inc.
- Provid Pharmaceuticals Inc.
- Purely Proteins
- Pyxis Discovery
- Quantum Pharmaceuticals
- Quintiles Transnational Corp.
- Regulus Therapeutics
- Reliance Life Sciences
- Renovis
- Rib-X Pharmaceuticals
- Ricerca, LLC
- RMC Biosciences, Inc.
- Roche R&D Center Ltd.
- Sai Advantium Pharma Ltd.
- Scottish Biomedical
- Scynexis, Inc.
- Selcia Limited
- SelciaWest
- Selvita S.A.
- Sequenom
- Sequitur, Inc.
- Shanghai GenMed
- Shanghai Genomics
- Shanghai LeadChem, subsidiary of Shanghai LeadDiscovery Pharmaceutical, Ltd.
- Shanghai LeadDiscovery Pharmaceutical, Ltd.
- Shanghai Medicilon
- Shanghai United PharmaTech
- Shasun Pharmaceuticals Ltd.
- Shenogen Pharma Group
- Shionogi & Co., Ltd.
- Shire plc
- Signature BioScience Inc.
- Simulations Plus, Inc.
- SomaLogic Inc.
- Southern Research Institute
- SPECS
- Spectrum Bioscience
- SRI Biosciences
- Structural Bioinformatics, Inc.
- Structural GenomiX
- Sun Pharma Advanced Research Company
- Sundia MediTech Company, Ltd./China
- Sundia MediTech Company, Ltd.
- Sunesis Pharmaceuticals
- Suven Life Sciences Ltd
- Sygnature Discovery Limited
- Synaptica Ltd.
- Syngene International Pvt. Ltd./India
- Syngene International Pvt. Ltd.
- Syrrx
- TCG Lifesciences Limited
- Targeted Molecules Corp.
- Torcan Chemical Ltd.
- Transform Pharmaceuticals Inc.
- Venturepharm Group
- Vertex Pharmaceuticals Inc.
- Viva Biotech Ltd.
- Vivo Biosciences Inc.
- WIL Research U.S.
- WIL Research Europe/The Netherlands
- WIL Research Europe/France
- WIL Research/UK
- WuXI AppTec Co. Ltd.
- WuXi AppTec, Inc.
- WuXi AppTec, Inc.
- Xencor
- Yangtze River Pharmacy Group Co
- ZoBio BV
- Zygogen, LLC
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